MassIVE MSV000095017

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Human IgG subclasses differ in structural elements of their N-glycosylation

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Description

We tested tryptic plasma samples using HILIC-LC-MS/MS, which included mixed human plasma as well as plasma from two healthy individuals collected at three different time points, approximately one month apart. Our focus was on the glycan structure of the Fc domain of IGG subclasses. The results indicated that each IGG subclass possesses a distinct glycan signature. Although there were slight variations between individuals, the glycan signature of IGG subclasses in individual plasma remained stable over time. [doi:10.25345/C50V89V1K] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: IgG subclasses ; human plasma

Contact

Principal Investigators:
(in alphabetical order) 		Karli Reiding, Utrecht University, The Netherlands
Submitting User: WeiweiWANG

Publications

Wang W, Maliepaard JCL, Damelang T, Vidarsson G, Heck AJR, Reiding KR.
Human IgG Subclasses Differ in the Structural Elements of Their N-Glycosylation.
ACS Cent Sci. 2024 Nov 27;10(11):2048-2058. Epub 2024 Oct 10.

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