MassIVE MSV000097802

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A multi-organ aging metabolomics model of a pro-drug activation deficiency murine model

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Description

Wild type and creatine kinase knock-out mice were subjected to a multi-organ metabolomic and proteomics comparative analysis using a streamline sample preparation method which allowed both metabolite and proteomic analysis of each organ. The metabolites were spiked with an heavy internal reference metabolite standards and analyzed using optimized reverse phase HPLC analysis in both positive and negative mode on a Q Exactive Classic. A reference standard library consisting of over 600 reference metabolite standards were analyzed on this system for extra confidence in the identification and quantification of this library of key metabolites. This repository solely contains the metabolomic data. A second repository will contain the matched proteomic data. [doi:10.25345/C52J68H3D] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Metabolomics ; Aging ; Creatine kinase ; Multi-omics ; Drug activation ; DatasetType:Metabolomics

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Principal Investigators:
(in alphabetical order) 		Ben Orsburn, University of Pittsburgh, USA
Submitting User: ben_orsburn
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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