MassIVE MSV000087858

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Discovery of novel macrolides: Epemicins A and B

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Description

Identification of two novel 30-membered glycosylated macrolides, epemicins A and B from the rare Kutzneria sp. CA-103260 with formulas C70H122N2O27 and C76H132N2O32. We also provide data on the successful heterologous expression of epemicin A in S. albus J1074 and on the abolishment of the production of the compounds via the generation of a knockout strain. The whole genome sequence of Kutzneria sp. CA-103260 available at: https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=2802641&lvl=3&lin=f&keep=1&srchmode=1&unlock The published data are available at: https://pubs.acs.org/doi/full/10.1021/acschembio.1c00318 [doi:10.25345/C5582K] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Epemicins A and B ; Macrolides ; Rare Actinomycete ; Actinomycete ; Kutzneria

Contact

Principal Investigators:
(in alphabetical order) 		Karl Tilmann Weber, DTU, Denmark
Submitting User: eeko
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