MassIVE MSV000081328

Partial Public PXD007047

Proteomic analysis of antigen-specific serum and gut antibodies in celiac disease patients


Comparison of serum and gut antibodies against two major antigens in celiac disease patients, the autoantigen transglutaminase 2 (TG2) and a deamidated gluten peptide (DGP) from food. The antigen-specific antibodies were affinity-purified from isolated total IgA of serum or gut biopsy secretions or from whole serum samples. Individual clonotypes could be identified among the purified antibodies based on matching to a database of IgH sequences obtained from antigen-specific gut plasma cells of the same patients. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Mucosal immune response, serum antibodies, IgA, celiac disease


Principal Investigators: Ludvig M. Sollid, University of Oslo, Norway
Submitting User: riversen
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