MassIVE MSV000086620

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GNPS From prevention to disease perturbations: A multi-omic assessment of exercise and myocardial infarctions

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Description

While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases like cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g. exercise) differ from that occurring due to injury caused from the disease (e.g. myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly different lipidomic perturbations were observed between these events as could be expected from their vastly different stresses on the body. The lipidomic results were then combined with previously published metabolomic characterizations on the same patients. This integration provided complementary insight into the exercise and PMI events, thereby giving a more holistic understanding of the molecular changes associated with each. [doi:10.25345/C5JR36] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: lipidomics, metabolomics, multi-omics, planned myocardial infarction (PMI), myocardial infarction (MI), exercise, heart

Contact

Principal Investigators:
(in alphabetical order) 		Erin Baker, North Carolina State University, United States
Submitting User: ebaker
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GNPS content goes here (MSV000086620 [task=8265d9de0536419ea7dc9f5a873a5af4])
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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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