MassIVE MSV000095573

Partial Public PXD054821

Acetate enhances long-term memory in female mice by sex-, context-, and brain region–specific epigenetic and transcriptional remodeling

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Description

Metabolic control of chromatin and gene expression is emerging as a key mechanism influencing critical neuronal functions. Here, we found that the intermediary metabolite acetate enhanced long-term memory in female mice, and this was associated with epigenetic and transcriptional remodeling in the dorsal hippocampus. Acetate-enhanced memory was driven by increased acetylation of the histone variant H2A.Z and increased expression of genes implicated in spatial learning, in the female dorsal hippocampus. The effect of acetate on dorsal hippocampal histone modifications and gene expression differed markedly between the sexes during critical windows of memory consolidation and recall, and home cage exposure to acetate without the learning and memory tasks did not recapitulate these effects. These findings elucidate a role for the metabolite acetate in regulating dorsal hippocampal chromatin and gene expression, and this work outlines the ways in which acetate exposure enhances learning and memory. Here, we have deposited the raw data for the mass spectrometry experiments in this study. [doi:10.25345/C55M62J9W] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: acetate ; histone modifications ; H2A.Z acetylation ; spatial memory ; dorsal hippocampus ; gene expression ; mouse ; cortex ; learning ; memory ; novel object location ; novel object recognition ; behavior

Contact

Principal Investigators:
(in alphabetical order) 		Gabor Egervari, Washington University School of Medicine, USA
Submitting User: egervari

Publications

EM Periandri, KM Dodson, FN de Luna Vitorino, BA Garcia, KM Glastad, G Egervari.
Acetate enhances long-term memory in female mice by sex-, context-, and brain region-specific epigenetic and transcriptional remodeling.
Sci Signal. 2026 Feb 24;19(926):eaec0496. Epub 2026 Feb 24.

Erica M Periandri, Kala M Dodson, Francisca N de Luna Vitorino, Benjamin A Garcia, Karl M Glastad, Gabor Egervari.
Acetate enhances spatial memory in females via sex- and brain region-specific epigenetic and transcriptional remodeling.
bioRxiv. Epub 2024 Aug 27. DOI: 10.1101/2024.08.26.609729.

Erica M Periandri, Kala M Dodson, Francisca N de Luna Vitorino, Benjamin A Garcia, Gabor Egervari.
Acetate enhances long-term memory in female mice by sex-, context-, and brain region–specific epigenetic and transcriptional remodeling.
Sci. Signal. 2026 Feb;19:eaec0496. DOI: 10.1126/scisignal.aec0496.

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