MassIVE MSV000100009

Complete Public PXD071153

The E3 ubiquitin ligase MGRN1 targets melanocortin receptors MC1R and MC4R via interactions with transmembrane adapters

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Description

MGRN1, a membrane-anchored E3 ligase, uses multiple transmembrane adapters-including newly identified ATRN and ATRNL1-to target specific surface receptors for ubiquitination and degradation. These adapters bind the RING domain of MGRN1 and enable it to regulate melanocortin receptors MC1R and MC4R in a manner similar to its known control of Smoothened. Loss of MGRN1 increases surface levels of these receptors and boosts eumelanin production, revealing an expanded and unifying mechanism for receptor-specific regulation by membrane-tethered E3 ligases. [doi:10.25345/C5707X23V] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: MGRN1 ; E3 ubiquitin ligase ; transmembrane ; transmembrane adapter proteins ; melanocortin receptors ; GPCR trafficking ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Jennifer Kong, University of Washington, USA
Submitting User: mriffle
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