This data set belongs to the publication 'Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders' from Xuewei Wu et al (PI: Poulikos I. Poulikakos) and contains the mass spectrometry files for affinity purification of endogenous CDK6 from tumor cell lines either sensitive or resistant to CDK4/6 inhibitors. The data showed a higher degree of interaction of CDK6 with components of the HSP90/CDC37 chaperoning complex in CDK4/6i-sensitive compared to CDK4/6i-resistant cells.
[doi:10.25345/C5RJ64]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: CDK6 complex ; affinity purification ; CDK4/6 inhibitors
Principal Investigators: (in alphabetical order) |
Beatrix Ueberheide, NYU Grossman School of Medicine, USA |
Submitting User: | Trixi |
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Owner | Reanalyses | |
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