MassIVE MSV000092542

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Subtiligase N-terminomics for identification of cleavage sites in mice brain and immunoprecipitated PrP

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Description

Subtiligase-based N-terminomics (Abu N-terminal tagging) of whole mouse brain and immunoprecipitated prion protein. Mouse expressing either WT or mutant (S3) form of PrP were used in this study. Five replicates for single brain experiments and one replicate for combined brains approach are included. For labeling of PrP, 2 biological replicates are part of the study. [doi:10.25345/C5P844629] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Mouse ; Brain ; N-terminomics ; Subtiligase ; PrP ; Cleavage sites ; Prion

Contact

Principal Investigators:
(in alphabetical order) 		Olivier Julien, University of Alberta, Canada
Submitting User: julienlab

Publications

Gomez-Cardona E, Eskandari-Sedighi G, Fahlman R, Westaway D, Julien O.
Application of N-Terminal Labeling Methods Provide Novel Insights into Endoproteolysis of the Prion Protein in Vivo.
ACS Chem Neurosci. 2024 Jan 3;15(1):134-146. Epub 2023 Dec 14.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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