MassIVE MSV000097955

Complete Public PXD064162

Integrated multi-omic analysis reveals novel subtype-specific regulatory interactions in pediatric B-cell acute lymphoblastic leukemia

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Description

In this study, we performed proteomic and phosphoproteomic profiling of B-cell acute lymphoblastic leukemia (B-ALL) samples collected at diagnosis and remission from pediatric leukemia patients with one of two subtypes of B-ALL: BCR::ABL1-like (Ph-like) and ETV6::RUNX1. We analyzed each dataset, as well as existing RNAseq data at diagnosis, to identify subtype-specific features, including increased calcium-dependent signaling in Ph-like samples. We then performed an integrated analysis of all three datasets, which enabled us to identify multiple layers of regulation, including subtype-specific phosphorylation of known cancer-associated proteins. Taken together, these data add to our understanding of the molecular profile of Ph-like and ETV6::RUNX1 B-ALL, demonstrating the utility of multi-omic comparison in pediatric leukemia subtype characterization. [doi:10.25345/C5F47H64D] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: B-cell acute lymphoblastic leukemia ; multiomics ; phosphoproteomics ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Midhat S Farooqi, Children's Mercy Hospital, USA
Submitting User: KUMC_Prot

Publications

Irina Pushel, Zachary S. Clark, Lisa A. Lansdon, Byunggil Yoo, Michaella J. Rekowski, Nicole M. Wood, Michael P. Washburn, Midhat S. Farooq.
Integrated Multi-Omic Analysis Reveals Novel Subtype-Specific Regulatory Interactions in Pediatric B-Cell Acute Lymphoblastic Leukemia.
Cancers 2026, 18(5), 813; https://doi.org/10.3390/cancers18050813.

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