MassIVE MSV000090272

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Effect of in utero and lactational exposure to a thyroid hormone system disrupting chemical on mouse metabolome

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Description

In the current study we use untargeted transcriptomic and metabolomic analyses to address the consequence of in utero and lactational exposure to a low dose of the model thyroid hormone system disrupting chemical propyl-thio-uracyl (PTU) in mice.We detected minor changes in gene expression in the brain, and of the metabolite content of the serum. Fatty acid and lipid metabolites were the most noteworthy markers in serum. [doi:10.25345/C5H98ZJ1J] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: metabolomics, toxicology, endocrine disruption, thyroid hormone system disruption,

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Principal Investigators:
(in alphabetical order) 		Martin Hansen, Aarhus University, Denmark
Submitting User: Rikke
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