MassIVE MSV000095229

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GNPS - Cardiomyocyte-specific NAMPT Knockout Mice: Targeted Metabolomics for NAD Derivatives from Heart Ventricle Tissues

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Description

Targeted metabolomics for NAD-related metabolites from heart ventricular tissues of wild-type (WT) and cardiomyocyte-specific conditional NAMPT (cNKO) mice untreated or treated with nicotinamide riboside (cNKO-NR), harvested at 8-weeks post-NAMPT deletion. Mass spectrometer was operated in two positive-mode scans (SCAN1 at 118.5 to 800 m/z and SCAN2 at 70 to 117.5 m/z) with the HILIC 20-minute method for the detection of NAD derivatives. [doi:10.25345/C5MK65K98] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Heart, NAMPT, Cardiomyocyte, Metabolomics, NAD

Contact

Principal Investigators:
(in alphabetical order) 		Joseph A. Baur, University of Pennsylvania, USA
Submitting User: Khanh_UPenn_Baur
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Identification Results
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GNPS content goes here (MSV000095229 [task=a20cfeb2ee4a401cb89070971d2feeb2])
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Distinct condition labels are counted across all files submitted in the "Metadata" category having a "Condition" column in this dataset.

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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

Distinct replicate labels are counted across all files submitted in the "Metadata" category having a "BioReplicate" or "Replicate" column in this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.