Metabolic signature of HepaRG cells exposed to ethanol and tumor necrosis factor alpha to study ethanol-induced hepatotoxicity by LC-MS-based untargeted metabolomics.
Dataset contains .mzML files originating from an LC-QTOF (6530 for metabolomics & 6560 for lipidomics). HepaRG samples were exposed to ethanol, ethanol & TNF-alpha or no ethanol and TNF-alpha (i.e. negative control). In addition, data from extraction blanks and QC pooled samples are available. Both intracellular and extracellular extracts were analyzed on four different platforms (metabolomics in ESI+ and ESI- and lipidomics in ESI+ and ESI-).
[doi:10.25345/C50R9M830]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: High-resolution mass spectrometry ; Liquid chromatography ; Metabolomics ; Lipidomics ; Alcoholic liver disease ; Steatohepatitis ; Hepatocytes ; HepaRG ; Steatosis ; Alcohol ; Ethanol ; Tumor necrosis factor alpha
Principal Investigators: (in alphabetical order) |
Elias Iturrospe, University of Antwerp, Belgium |
Submitting User: | EliasI |
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Owner | Reanalyses | |
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