MassIVE MSV000096432

Complete Public PXD057949

MEF2A, MEF2C, and MEF2D Interactomes in Mouse MA-10 Leydig Cells

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Description

In steroidogenic Leydig cells, MEF2A, MEF2C, and MEF2D are key regulators of genes involved in steroid hormone synthesis, reproductive function, and oxidative stress defense. Here we used TurboID proximity-mediated biotinylation to map the protein-protein interaction networks of MEF2A, MEF2C, and MEF2D in mouse MA-10 Leydig cells. Interactions were captured under both basal (unstimulated) and forskolin-stimulated conditions to examine differences in the MEF2 interactomes in relation to steroidogenesis. This dataset provides insights into MEF2-related signalling pathways and the functional landscape of MEF2 transcription factors in Leydig cells. [doi:10.25345/C5S46HJ34] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: protein-protein interaction, transcription factors, steroidogenesis, TurboID, proximity labelling, Leydig cells ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Jacques J Tremblay, Universite Laval, Canada
Submitting User: JJTremblay01

Publications

de Mattos K, Scott-Boyer MP, Droit A, Viger RS, Tremblay JJ.
Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk-stimulated mouse MA-10 Leydig cells.
Andrology. Epub 2025 Apr 25. doi: 10.1111/andr.70051.

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