We have developed a composite infection vaccine technology (ciVAX) assembled from approved products for rapid response to pandemics and biothreat agents. ciVAX consists of an injectable biomaterial scaffold containing factors that recruit, reprogram and release dendritic cells (DC) in vivo. For bacterial infections, ciVAX contains Fc-Mannose-Binding Lectin (FcMBL) microbeads with captured PAMPs fractions from inactivated bacterial cell-wall lysates. ciVAX vaccination generates potent humoral and T cell responses to bacterial antigens, and ciVAX protects mice and pigs against lethal E coli challenge in sepsis and septic shock models
[doi:10.25345/C5XB70]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: composite infection vaccine technology (ciVAX), Fc-Mannose-Binding Lectin (FcMBL) microbeads, T cell responses to bacterial antigens
Principal Investigators: (in alphabetical order) |
David J Mooney, Harvard John A. Paulson School of Engineering and Applied Sciences, USA |
Submitting User: | bbudnik |
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Owner | Reanalyses | |
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