MassIVE MSV000082754

Partial Public PXD010707

Cadmium exposure negatively impacts immune response, proteins synthesis and energy metabolism in Anopheles gambiae larvae

Description

Cadmium is one of the widely used Heavy metals in commercial and industrial products and contributes to environmental contamination in urban settings. Heavy metal toxicity comes with a fitness cost to insects. Here we investigated the proteome of the malaria mosquito An. gambiae lava after multigenerational exposure to cadmium at physiologically relevant concentrations and observed the disregulation of larval immunity, energy metabolism, antioxidant enzymes among other biological processes. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Cadmium tolerance, Mosquito, Anopheles gambiae, Larvae, Proteome

Contact

Principal Investigators: James M. Njunge, KEMRI-Wellcome.org, Kenya
Martin Rono, KEMRI-Wellcome Trust Research Programme, Kenya
Paul O. Mireji, Biotechnology Research Institute - Kenya Agriculture and Livestock Research Organization, Kenya
Submitting User: njunge
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Experimental Design
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Identification Results
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Number of distinct conditions across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

The technical replicate count is defined as the maximum number of times any one distinct combination of condition and biological replicate was analyzed across all files submitted in the "Metadata" category. In the case of fractionated experiments, only the first fraction is considered.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.