MassIVE MSV000080722

Imported Reanalysis Dataset Public PXD002279

SLC12A3 isoforms in human urine exosomes

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Description

The thiazide-sensitive NaCl cotransporter (NCC) is an important pharmacological target in the treatment of hypertension. Human SLC12A3 gene encoding NCC gives rise to three isoforms. Only the isoform 3 has been extensively investigated. The goal of the present study was, therefore, to determine the abundance and localization of NCC1 and NCC2 in comparison to NCC3 in the human kidney as well as their functional properties in physiological and pathological conditions. To this end, the presence of NCC1, NCC2, and NCC3 in the human urinary exosomes was assessed by mass spectrometric analysis. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Human ; urine ; label-free ; exosomes ; isoforms

Contact

Principal Investigators:
(in alphabetical order) 		Connie Ramona Jimenez, OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands, N/A
Submitting User: ccms

Publications

Tutakhel OA, Jele? S, Valdez-Flores M, Dimke H, Piersma SR, Jimenez CR, Deinum J, Lenders JW, Hoenderop JG, Bindels RJ.
Alternative splice variant of the thiazide-sensitive NaCl cotransporter: a novel player in renal salt handling.
Am. J. Physiol. Renal Physiol. 2016 Feb 1;310(3):F204-16. Epub 2015 Nov 11.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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