Here, we performed proteomics on whole cell lysate of three high-grade serous ovarian cancer patient derived cancer associated fibroblast (CAF) lines, four commercially available high-grade serous ovarian epithelial cancer cell lines (Kuramochi, PEO4, OVCAR8, ES2) and two immortalized normal Fallopian tube secretory epithelial cell lines (FT237, FT194). N-glycoproteomics using hydrazide-based enrichment was performed on 8/9 models. Integration of data from in vitro models with publicly available primary tissue data identified multiple novel CAF proteins that are associated with poor clinical outcomes in HGSC.
[doi:10.25345/C5930P051]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: High-grade serous ovarian cancer ; Cancer associated fibroblast ; N-glycoproteomics ; Cell lines ; In vitro
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Dr. Thomas Kislinger, Princess Margaret Cancer Centre, Canada |
Submitting User: | TKislinger |
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