MassIVE MSV000082272

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Mouse muscle mitochondrial proteome changes in high fat diet vs. low fat diet

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Description

We investigated remodeling of the mitochondrial proteome to determine mechanisms of changes to lipid oxidation following high-fat feeding. C57BL/6J mice consumed either a high-fat diet (HFD, 60% fat) or low fat diet (LFD, 10% fat) for 12 weeks. Mice were fasted 4 hours then anaesthetized by sodium pentobarbital for tissue collection. A mitochondrial-enriched fraction was prepared from gastrocnemius muscles and underwent proteomic analysis by high-resolution mass spectrometry. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: skeletal muscle ; mitochondrial ; proteome ; high fat diet

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Principal Investigators:
(in alphabetical order) 		Matthew Robinson, Oregon State Univeristy, USA
Submitting User: surendradasari
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