MassIVE MSV000086735

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Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria: metabolomics

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Description

We analyzed changes in cellular components and processes during NiV infection through a time-course exposure using live virus and individual genes (or combinations) via transfection. Our multi-omics approach has displayed an enrichment in mitochondrial proteins. This enrichment phenotype was also observed when we combine viral glycoprotein genes in transfection experiments. These analyses provide an atlas of cellular changes during NiV infections, helpful in designing therapeutics against rapidly growing Henipavirus genes and related infections. [doi:10.25345/C5VJ62] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Nipah virus ; paramyxovirus ; transcriptomics ; metabolomics ; metabolism ; infection

Contact

Principal Investigators:
(in alphabetical order) 		Hector Aguilar-Carreno, Department of Microbiology and Immunology, Cornell University, United States
Joshua N. Adkins, Pacific Northwest National Laboratory, USA
Submitting User: alchemistmatt

Publications

Johnston GP, Aydemir F, Byun H, de Wit E, Oxford KL, Kyle JE, McDermott JE, Deatherage Kaiser BL, Casey CP, Weitz KK, Olson HM, Stratton KG, Heller NC, Upadhye V, Monreal IA, Reyes Zamora JL, Wu L, Goodall DH, Buchholz DW, Barrow JJ, Waters KM, Collins RN, Feldmann H, Adkins JN, Aguilar HC.
Multi-platform omics analysis of Nipah virus infection reveals viral glycoprotein modulation of mitochondria.
Cell Rep. 2025 Mar 25;44(3):115411. Epub 2025 Mar 17.

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