Mice were infected with Trypanosoma cruzi strains CL, X10/4 or X10/7. Hearts were collected 12 days, 3 months and 5 months post-infection from infected mice and uninfected age-matched controlled. Hearts were divided into four sections from the base of the heart to the apex. Metabolites were extracted by a two-step protocol, first with 50% methanol (aqueous extract) then with 3:1 dichloromethane:methanol (organic extract). Liquid chromatography separation was performed on a Kinetex C8 LC Column 50 x 2.1 mm, with water+0.1% formic acid and acetonitrile+0.1% formic acid as mobile phases.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Trypanosoma cruzi ; Chagas disease ; heart sections ; cell culture ; parasite ; acute ; chronic
Principal Investigators: (in alphabetical order) |
James McKerrow, UCSD, USA Laura-Isobel McCall, UCSD, USA |
Submitting User: | lamccall |
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Owner | Reanalyses | |
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