These data accompany our publication "RIT1 oncoproteins escape LZTR1-mediated proteolysis" (Castel P., et al. Science, 2019).
Experiment 1:
Identification of LZTR1 as an interacting partner of RIT1
Q Exactive Plus
P20161208-02 FLAG GFP
P20161208-03 FLAG RIT1
LTQ Orbitrap Velos
V20170407-01 GST empty vector
V20170407-03 GST RIT1
V20170407-06 HA empty vector
V20170407-07 HA RIT1
Experiment 2:
Identification of K135 and K187 ubiquitination sites in RIT1
Q Exactive Plus
P20180408-01 FLAG-RIT1 / empty vector / empty vector (replicate 1)
P20180408-02 FLAG-RIT1 / LZTR1 / empty vector (replicate 1)
P20180408-03 FLAG-RIT1 / empty vector / TUBE (replicate 1)
P20180408-04 FLAG-RIT1 / LZTR1 / TUBE (replicate 1)
P20180408-06 GST-RIT1 / empty vector / empty vector (replicate 1)
P20180408-07 GST-RIT1 / LZTR1 / empty vector (replicate 1)
P20180408-08 GST-RIT1 / empty vector / TUBE (replicate 1)
P20180408-09 GST-RIT1 / LZTR1 / TUBE (replicate 1)
P20180408-11 GST-RIT1 / empty vector / empty vector (replicate 2)
P20180408-12 GST-RIT1 / LZTR1 / empty vector (replicate 2)
P20180408-13 GST-RIT1 / empty vector / TUBE (replicate 2)
P20180408-14 GST-RIT1 / LZTR1 / TUBE (replicate 2)
P20180408-16 FLAG-RIT1 / empty vector / empty vector (replicate 2)
P20180408-17 FLAG-RIT1 / LZTR1 / empty vector (replicate 2)
P20180408-18 FLAG-RIT1 / empty vector / TUBE (replicate 2)
P20180408-32 FLAG-RIT1 / LZTR1 / TUBE (replicate 2)
[doi:10.25345/C54315]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: RIT1 ; LZTR1 ; Ubiquitination
Principal Investigators: (in alphabetical order) |
Anatoly Urisman, University of California, San Francisco, USA |
Submitting User: | anatolyu |
Castel P, Cheng A, Cuevas-Navarro A, Everman DB, Papageorge AG, Simanshu DK, Tankka A, Galeas J, Urisman A, McCormick F.
RIT1 oncoproteins escape LZTR1-mediated proteolysis.
Science. 2019 Mar 15;363(6432):1226-1230.
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