Metastasis to the brain is rare in prostate cancer and unfortunately, incredibly lethal. We evaluated the tissue biopsies of a patient with a treatment-induced metastatic lesion to the brain of the neuroendocrine prostate cancer (NEPC) subtype. We performed genomic, transcriptomic, and proteomic characterization on the primary prostate tumor, the metastatic brain NEPC, and an additional metastatic nodule in the dura with adenocarcinoma histology. These data are the proteomics result of this patient, with three replicates for each sample (primary prostate, dura adenocarcinoma, brain NEPC).
[doi:10.25345/C59882Z7V]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Proteomics ; Prostate Cancer ; Neuroendocrine ; Adenocarcinoma ; Biopsy Tissue ; Brain Metastasis ; Case Report
Principal Investigators: (in alphabetical order) |
Justin M. Drake PhD, University Minnesota, United States |
Submitting User: | mlludwig |
Megan L. Ludwig, David Moline, Alec Horrmann, Ella Boytim, Gabrianne Larson, Ali T. Arafa, Masooma Sayeda, John R. Lozada, Hannah E. Bergom, Abderrahman Day, Sandhyarani Dasaraju, Scott M. Dehm, Paari Murugan, Justin Hwang, Justin M. Drake & Emmanuel S. Antonarakis.
Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases.
Ludwig, M.L., Moline, D., Horrmann, A. et al. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. npj Precis. Onc. 8, 215 (2024). https://doi.org/10.1038/s41698-024-00713-8.
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