MassIVE MSV000095007

Partial Public PXD053050

Integrated multi-omics assessment of lineage plasticity features in a prostate cancer patient with brain and dural metastases

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Description

Metastasis to the brain is rare in prostate cancer and unfortunately, incredibly lethal. We evaluated the tissue biopsies of a patient with a treatment-induced metastatic lesion to the brain of the neuroendocrine prostate cancer (NEPC) subtype. We performed genomic, transcriptomic, and proteomic characterization on the primary prostate tumor, the metastatic brain NEPC, and an additional metastatic nodule in the dura with adenocarcinoma histology. These data are the proteomics result of this patient, with three replicates for each sample (primary prostate, dura adenocarcinoma, brain NEPC). [doi:10.25345/C59882Z7V] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Proteomics ; Prostate Cancer ; Neuroendocrine ; Adenocarcinoma ; Biopsy Tissue ; Brain Metastasis ; Case Report

Contact

Principal Investigators:
(in alphabetical order) 		Justin M. Drake PhD, University Minnesota, United States
Submitting User: mlludwig

Publications

Megan L. Ludwig, David Moline, Alec Horrmann, Ella Boytim, Gabrianne Larson, Ali T. Arafa, Masooma Sayeda, John R. Lozada, Hannah E. Bergom, Abderrahman Day, Sandhyarani Dasaraju, Scott M. Dehm, Paari Murugan, Justin Hwang, Justin M. Drake & Emmanuel S. Antonarakis.
Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases.
Ludwig, M.L., Moline, D., Horrmann, A. et al. Integrated multi-omics assessment of lineage plasticity in a prostate cancer patient with brain and dural metastases. npj Precis. Onc. 8, 215 (2024). https://doi.org/10.1038/s41698-024-00713-8.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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