MassIVE MSV000093071

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RIME Analysis of HNF4A binding partners in the intestinal epithelium

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Description

The mechanisms driving gene expression changes during intestinal differentiation are unclear. Our studies have shown differential recruitment and occupancy of Pol II to be a major driver of these gene expression changes. Additionally, we have identified the transcription factor HNF4 as a key player in shaping this phenomenon. To gain insights into the protein-based mechanisms underlying HNF4-mediated Pol II recruitment, we performed RIME (Rapid Immunoprecipitation Mass Spectrometry of Endogenous proteins) using anti-HNF4A antibodies in primary mouse epithelium. [doi:10.25345/C56H4D16C] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: RIME, HNF4A, Intestine

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Principal Investigators:
(in alphabetical order) 		Michael P Verzi, Rutgers, The State University of New Jersey, USA
Submitting User: kvemuri
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