MassIVE MSV000092401

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LCMSMS Quantitation of HILIC Enriched N glycopeptides derived from low abundance serum glycoproteins in patients with Narcolepsy Type I

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Description

Glycoproteomics analysis is always challenging because of low abundance and complex site-specific heterogeneity. Glycoproteins are involved in various biological processes such as cell signaling, adhesion, and cell cell communication and may serve as potential biomarkers when analyzing different diseases. Here, we study glycoproteins in Narcolepsy Type I disease, a variant of narcolepsy characterized by cataplexy the sudden onset of muscle weakness usually caused by strong emotions. There is currently no cure for this life-altering disease. Therefore, it is crucial to identify biomarkers to improve the diagnosis of narcolepsy type I. In this study, 27 blood serum samples were analyzed, of which 16 were from Narcolepsy type-I patients, and 11 were controls. We quantified enriched glycoproteins by LCMSMS. [doi:10.25345/C5513V60K] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: NT1, HILIC-enriched N-glycopeptides, Biomarker glycoproteins.

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Principal Investigators:
(in alphabetical order) 		Yehia Mechref, Texas Tech University, United States
Submitting User: Moji
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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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