MassIVE MSV000084120

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Epicardial transplantation of atrial micrografts

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Description

Ischemic heart disease remains the leading cause of mortality and morbidity worldwide despite improved possibilities in medical care. Alongside interventional therapies, such as coronary artery bypass grafting (CABG), adjuvant tissue-engineered and cell-based treatments can provide regenerative improvement. Unfortunately, most of these advanced approaches require multiple lengthy and costly preparation stages without in turn delivering significant clinical benefit. Here, we investigated the effect of epicardial matrix patch-encased atrial appendage micrografts (AAMs) in a mouse model of myocardial infarction. The matrix-covered AAM patches salvaged the myocardium from infarction-induced functional tissue loss. Fibrosis was attenuated, and site-targeted proteomics revealed AAM patch-activated pathways for angiogenesis and cardiogenesis. The matrix component of the graft further supports functional myocardial recovery by ventricular unloading. The composite epicardial matrix graft encasing AAM micrografts delivers effects desirable for adjuvant cardiac therapy preserving functional cardiac tissue and restricting fibrosis after myocardial infarction. [doi:10.25345/C55D3B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Atrial appendage, Micrografts, Cardiac regeneration, Myocardial infarction

Contact

Principal Investigators:
(in alphabetical order) 		Esko Kankuri, University of Helsinki, Medicum, Dept. of Pharmacology, Finland
Submitting User: MaciejLalowski

Publications

Xie Yanbo, Milla Lampinen, Juuso Takala, Vilbert Sikorski, Rabah Soliymani, Miikka Tarkia, Maciej Lalowski, Eero Mervaala, Markku Kupari,Zhe Zheng, Shengshou Hu, Ari Harjula, Esko Kankuri on behalf of the AADC consortium.
Journal of Heart and Lung Transplantation.
https://doi.org/10.1016/j.healun.2020.03.023.

Xie Yanbo*, Milla Lampinen*, Juuso Takala*, Vilbert Sikorski*, Rabah Soliymani, Miikka Tarkia, Maciej Lalowski, Eero Mervaala, Markku Kupari, Zhe Zheng, Shengshou Hu, Ari Harjula, Esko Kankuri on behalf of the AADC consortium.
Myocardial salvage from infarction-induced destruction by an epicardial patch transplant encasing atrial appendage micrografts.
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