MassIVE MSV000083257

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PPARG interactions with UBR5 and MRE11-RAD50-NBS1 are required for DNA damage response and repair.

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Description

PPARG interactome datasets containing (1) Flag-PPARG AP-MS, identifying MRE11, RAD50 and NBS1 as novel interactors, (2) tandem-IP (in solution and silver fragments) of PPARG-Strep and Flag-NBS1, which identifies PPARG interaction with UBR5 (3) tandem-IP (same as 2) with BS3 cross-linking illustrates the binding interface between PPARG and NBS1. These mass spec data and other biochemical data demonstrate PPARG novel roles in promoting DNA damage response and repair, by activating the ATM pathway. [doi:10.25345/C5TG8T] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: dna damage response ; PPARG ; MRN

Contact

Principal Investigators:
(in alphabetical order) 		Marlene Rabinovitch, Stanford University, USA
Submitting User: gracelicy
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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