MassIVE MSV000083679

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TAK1 converts Sequestosome 1/p62 from an autophagy receptor to a signaling platform

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Description

The protein p62/Sequestosome 1 (p62) has been described as a selective autophagy receptor and independently as a platform for pro-inflammatory and other intracellular signaling. How these seemingly disparate functional roles of p62 are coordinated has not been resolved. Here we show that TAK1, a kinase involved in immune signaling, negatively regulates p62 action in autophagy. [doi:10.25345/C5TC95] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Tripartite-motif ; anti-inflammatory ; HIV-1 ; TLR3 ; TRIM5

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Principal Investigators:
(in alphabetical order) 		Mike Mandell, UNM, USA
Submitting User: awherren
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