In malignant B-cell context, application of affinity-purification mass spectrometry (AP-MS) on KLHL6 baits revealed novel physical protein interaction partners outside the established ubiquitination/protein degradation machinery, such as BCR signaling components CD79A and Bank1. As a complementary approach to AP-MS, Kelch-domain adjacent proximity-dependent labeling (BioID2) revealed potential substrates processed by the identified KLHL6-CRLs.
[doi:10.25345/C5CV4C27W]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: KLHL6
Principal Investigators: (in alphabetical order) |
Markku Varjosalo, University of Helsinki, Finland |
Submitting User: | XIOLIU |
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