KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein. KHSRP regulates transcription, mRNA decay and translation, and miRNA biogenesis that influence distinct functions associated with cancer cell biology, such as inflammation and cell-fate determination. However, the role KHSRP plays in colorectal cancer (CRC) tumorigenesis is largely unknown. Our study uncovered novel mechanistic-based data on the tumor-promoting effects of KHSRP in CRC, including the control by KHSRP of protein secreted by CRC epithelial cells, influencing the tumor-promoting microenvironment.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: KHSRP ; colorectal cancer
Principal Investigators: (in alphabetical order) |
Francesco Caiazza, University of California San Francisco, U.S.A. |
Submitting User: | fcaiazza |
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Owner | Reanalyses | |
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