MassIVE MSV000094441

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Molecular signatures of neurodegenerative diseases identified by proteomic and phosphoproteomic analyses in aging mouse brain

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Description

A central hallmark of neurodegenerative diseases is the irreversible accumulation of misfolded proteins in the brain by aberrant phosphorylation. Understanding the mechanisms underlying protein phosphorylation and its role in pathological protein aggregation within the context of aging is crucial for developing therapeutic strategies aimed at preventing or reversing such diseases. Here, we applied multi-protease digestion and quantitative mass spectrometry to compare and characterize dysregulated proteins and phosphosites in the mouse brain proteome using three different age groups: young-adult (3-4 months), middle-age (10 months), and old mice (19-21 months). Proteins associated with senescence, neurodegeneration, inflammation, cell cycle regulation, the p53 hallmark pathway, and cytokine signaling showed significant age-dependent changes in abundances and level of phosphorylation. The findings identify a significant association between aging and the dysregulation of proteins involved in various pathways linked to neurodegenerative diseases with potential therapeutic implications. [doi:10.25345/C5DZ03C5G] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: aging, neurodegenerative disease, proteomics, phosphoproteomics, protein aggregation

Contact

Principal Investigators:
(in alphabetical order) 		Uma K Aryal, Purdue University, United States
Submitting User: uma_aryal
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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