MassIVE MSV000084498

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Dysregulation of Amyloid Precursor Protein impairs adipose tissue mitochondrial function and promotes obesity

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Description

Mitochondria from subcutaneous white adipose tissues of control or signal recognition particle 54c (SPR54c) transgenic mice were isolated and underwent further Percoll gradient-based purification. Purified mitochondria were subject to mass-spectrometry based proteomic analysis performed by UT Southwestern Proteomics Core. ID# 696496: SRP54c Transgenic; ID# 696497: control. [doi:10.25345/C55384] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Obesity ; Adipocyte ; Amyloid precursor protein (APP) ; Mitochondrial Dysfunction ; Lipolysis ; Adipocyte Hypertrophy ; Signal Recognition Particle (SRP)

Contact

Principal Investigators:
(in alphabetical order) 		Philipp Scherer, Touchstone Diabetes Center, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA
Submitting User: mogoodarzi
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