MassIVE MSV000083480

Partial Public PXD012875

Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRAS-mut melanoma

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Description

These data support our manuscript "Selective abrogation of S6K2 maps lipid homeostasis as a survival vulnerability in MAPKi-resistant NRAS-mut melanoma". Proteomics was performed for M93-047 melanoma cells expressing vector control, S6K1 shRNA knockdown or S6K2 shRNA knockdown. [doi:10.25345/C5QP66] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: MAPKi-resistance ; NRAS ; Melanoma ; S6K2 ; S6K1 ; Lipid desaturation ; Ferroptosis ; Lipid peroxidation ; Oxidative cell death ; Cancer

Contact

Principal Investigators:
(in alphabetical order) 		Jessie Villanueva, The Wistar Institute, United States
Submitting User: agoldman
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