MassIVE MSV000100303

Partial Public PXD072292

PolG Exonuclease Activity in Cardiomyocytes from Mouse Heart

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Description

In vivo and human correlation study that identifies how mitochondrial DNA (mtDNA) instability triggers heart failure. By creating a mouse model with impaired cardiac mtDNA repair, this study Integrated Stress Response (ISR) activation and folate metabolism rewiring occur before heart function declines. Mice developed progressive cardiomyopathy and liver damage, providing a vital link between mitochondrial defects and systemic heart failure. To investigate this more broadly, we performed proteomic analysis on LVs from mice at 20, 24 and 28-weeks post-TAM, to gain a more global understanding of the molecular changes occurring in mutant hearts. [doi:10.25345/C5C824T77] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: heart ; Mitochondrial dysfunction ; Polymerase Gamma (PolG) ; heart failure ; mitochondria ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		David Greening, Baker Heart & Diabetes Institute, Australia
Submitting User: dwgree
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.