MassIVE MSV000086881

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Measuring Fucosylated Alpha-fetoprotein in Hepatocellular Carcinoma by Parallel Reaction Monitoring

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Description

Detection of HCC can improve the survival rate for patients with HCC. Thus, effective methods and biomarkers are required to improve the rate of early-HCC detection. We analyzed glycopeptides from AFP in the sera of patients with HCC and liver cirrhosis for the detection of HCC using LC-PRM with immunoprecipitation. Our results suggest that glycopeptide-based LC-PRM is a promising detection tool and that the relative percentage of fucosylated AFP is a clinically useful parameter for the detection of HCC. [doi:10.25345/C5CR41] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Alpha-fetoprotein ; Parallel Reaction Monitoring ; Hepatocellular Carcinoma

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Principal Investigators:
(in alphabetical order) 		Jong Shin Yoo, Korea Basic Science Institute, Rep of Korea
Submitting User: kwanghoekim
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