A better understanding of the proteomic profile after bipolar disorder (BD) and
schizophrenia (SCZ) treatment, through monitoring its progression, may assist
the development of novel therapeutic strategies with the ability to reduce or
control possible side effects. In this study, proteomics analysis employing liquid
chromatography coupled to mass spectrometry (LC-MS) and bioinformatic tools
were applied to identify differentially expressed proteins in serum of treated BD
and SCZ patients. In total, 10 BD patients, 10 SCZ patients, and 14 healthy
participants were included. From 25 serum proteins significantly altered (> 1.5-
fold change), 8 were down-regulated in the BD group, while 7 proteins were up-
regulated and 2 down-regulated in SCZ group when compared against healthy
controls. Bioinformatics analysis based on these 25 proteins validated two main
altered pathways previously described in the literature; furthermore, it revealed
that opposite expressions of the complement and coagulation cascades were
the most significant biological processes involved in these pathologies.
Associations of disease-proteins and pathways suggest therapeutic intervention
or prevention of comorbidities risks for BD and SCZ. Further validation and
investigation are required to define whether there is correlation between
complement and coagulation cascade expression for both diseases and
cardiovascular diseases.
[doi:10.25345/C5W19B]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Shotgun Proteomics ; Label-free ; MaxQuant ; Bipolar disorder ; Schizophrenia
Principal Investigators: (in alphabetical order) |
Alessandra Sussulini, Universidade Estadual de Campinas, Brasil |
Submitting User: | ElisaCSC |
Elisa Castañeda Santa Cruz, Flávia da Silva Zandonadi, Wagner Fontes, Alessandra Sussulini.
A pilot study indicating the dysregulation of the complement and coagulation cascades in treated schizophrenia and bipolar disorder patients.
Biochim Biophys Acta Proteins Proteom . 2021 Aug;1869(8):140657. doi: 10.1016/j.bbapap.2021.140657.
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