MassIVE MSV000086425

Partial Public PXD022417

Dysregulation of the complement and coagulation cascade in treated schizophrenia and bipolar disorder patients

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Description

A better understanding of the proteomic profile after bipolar disorder (BD) and schizophrenia (SCZ) treatment, through monitoring its progression, may assist the development of novel therapeutic strategies with the ability to reduce or control possible side effects. In this study, proteomics analysis employing liquid chromatography coupled to mass spectrometry (LC-MS) and bioinformatic tools were applied to identify differentially expressed proteins in serum of treated BD and SCZ patients. In total, 10 BD patients, 10 SCZ patients, and 14 healthy participants were included. From 25 serum proteins significantly altered (> 1.5- fold change), 8 were down-regulated in the BD group, while 7 proteins were up- regulated and 2 down-regulated in SCZ group when compared against healthy controls. Bioinformatics analysis based on these 25 proteins validated two main altered pathways previously described in the literature; furthermore, it revealed that opposite expressions of the complement and coagulation cascades were the most significant biological processes involved in these pathologies. Associations of disease-proteins and pathways suggest therapeutic intervention or prevention of comorbidities risks for BD and SCZ. Further validation and investigation are required to define whether there is correlation between complement and coagulation cascade expression for both diseases and cardiovascular diseases. [doi:10.25345/C5W19B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Shotgun Proteomics ; Label-free ; MaxQuant ; Bipolar disorder ; Schizophrenia

Contact

Principal Investigators:
(in alphabetical order) 		Alessandra Sussulini, Universidade Estadual de Campinas, Brasil
Submitting User: ElisaCSC

Publications

Elisa Castañeda Santa Cruz, Flávia da Silva Zandonadi, Wagner Fontes, Alessandra Sussulini.
A pilot study indicating the dysregulation of the complement and coagulation cascades in treated schizophrenia and bipolar disorder patients.
Biochim Biophys Acta Proteins Proteom . 2021 Aug;1869(8):140657. doi: 10.1016/j.bbapap.2021.140657.

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