MassIVE MSV000080219

Imported Reanalysis Dataset Public PXD001997

Protein accumulation post-LASIK surgery in granular corneal dystrophy type II patients involves altered proteolytic processing of transforming growth factor beta-induced protein (TGFBIp)

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Description

his study present the protein profile of diseased cornea from granular corneal dystrophy patients developing protein accumulation after LASIK surgery. Extracted ion chromatography (XIC) label free quantification was perform using Mascot Distiller software. In addition, 2D-PAGE followed by western blot against the mutated protein TGFBIp that cause the protein accumulation in the cornea, was examined and compared to normal corneal tissue. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Granular Corneal Dystrophy ; Cornea ; TripleTof 5600+ ; XIC quantification ; 2D-PAGE

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Principal Investigators:
(in alphabetical order) 		Dr Jan Johannes Enghild
Submitting User: ccms

Publications

Poulsen ET, Nielsen NS, Jensen MM, Nielsen E, Hjortdal J, Kim EK, Enghild JJ.
LASIK surgery of granular corneal dystrophy type 2 patients leads to accumulation and differential proteolytic processing of transforming growth factor beta-induced protein (TGFBIp).
Proteomics. 2016 Feb;16(3):539-43. Epub 2016 Jan 3.

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This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.