MassIVE MSV000098219

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Proteomic analysis of breast cancer cell lines MCF_7 and MDA_MB_468 treated with melatonin

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Description

Breast cancer (BC) is the most prevalent and lethal tumor among women worldwide. Although the antitumor effects of melatonin are well documented, its precise molecular mechanisms in specific breast cancer subtypes remain unclear. This dataset provides proteomic data from total protein extracts of two breast cancer cell lines [MCF-7 (ER+and PR+) and MDA-MB-468 (triple negative) treated with melatonin. The aim of the study was to identify melatonin-induced changes in global protein expression and to assess its potential as a therapeutic modulator in hormone-responsive and triple-negative breast cancer. [doi:10.25345/C51R6NC8B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Breast cancer ; Melatonin ; Proteomics ; DatasetType:Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Debora Aparecida Pires de Campos Zuccari, Faculty of Medicine of Sao Jose do Rio Preto (FAMERP), Brazil
Lucilene Delazari dos Santos, Program in Tropical Diseases and in Medical Biotechnology, Botucatu Medical School (FMB)/Biotechnology Institute (IBTEC), UNESP, Botucatu, SP, Brazil
Luiz Gustavo de Almeida Chuffa, Department of Structural and Functional Biology, Institute of Biosciences, UNESP, Botucatu, SP, Brazil
Roberta Carvalho Cesario, Department of Structural and Functional Biology, Institute of Biosciences, UNESP, Botucatu, SP, Brazil
Submitting User: lucilene
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Identification Results
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Quantification Results
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Number of distinct conditions across all analyses (original submission and reanalyses) associated with this dataset.

Distinct condition labels are counted across all files submitted in the "Metadata" category having a "Condition" column in this dataset.

"N/A" means no results of this type were submitted.
Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

Distinct replicate labels are counted across all files submitted in the "Metadata" category having a "BioReplicate" or "Replicate" column in this dataset.

"N/A" means no results of this type were submitted.
Number of distinct technical replicates across all analyses (original submission and reanalyses) associated with this dataset.

The technical replicate count is defined as the maximum number of times any one distinct combination of condition and biological replicate was analyzed across all files submitted in the "Metadata" category. In the case of fractionated experiments, only the first fraction is considered.

"N/A" means no results of this type were submitted.
Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

"N/A" means no results of this type were submitted.
Number of distinct protein accessions reported across all analyses (original submission and reanalyses) associated with this dataset.

"N/A" means no results of this type were submitted.
Number of distinct unmodified peptide sequences reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct peptide sequences (including modified variants or peptidoforms) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Total number of peptide-spectrum matches (i.e. spectrum identifications) reported across all analyses (original submission and reanalyses) associated with this dataset.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.