MassIVE MSV000090293

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Brevetoxin induces a shift in the redox state of the proteome and unfolded protein response in human lymphoblast cells that can be alleviated with the acrolein scavenger MESNA

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Description

Human lymphoblast cells (GM05581) were treated with (i) brevetoxin-2 (5 uM) or (ii) a combination of brevetoxin-2 (5 uM) and sodium 2-mercaptoethyl sulfonic acid (500 uM) or (iii) equal volume of vehicle (DMSO, control) for 24 h. Each sample is an iodoTMT6plex with 2 replicates of each of the above conditions. [doi:10.25345/C5NZ80V1S] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: brevetoxin ; red tide ; redox proteomics ; oxidative stress ; unfolded protein response ; ER stress

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Principal Investigators:
(in alphabetical order) 		Kathleen Rein, Florida International University, USA
Submitting User: jjotto
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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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