MassIVE MSV000088252

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Analysis of the Streptococcus mutans proteome during acid and oxidative stress reveals modules of co-expression and an expanded role for the TreR transcriptional regulator

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Description

Dental caries is the most common chronic infectious disease worldwide and disproportionally affects marginalized socioeconomic groups. Streptococcus mutans is a considered a primary etiologic agent of caries, with its pathogenicity dependent on coordinated physiologic stress responses that mitigate the damage caused by oxidative and acid stress, which are frequently encountered. In this study, the proteome of S. mutans was examined during growth in acidic and oxidative stresses, as well in nox and treR deletion mutants. 607 proteins were differentially expressed across the strains/growth conditions, and modules of co-expressed proteins were identified, which enabled mapping the acid and oxidative stress responses across S. mutans metabolism. The presence of TreR was linked to mutacin production via LytTR system signaling and to oxidative stress via mutanobactin production. The data provided by this study will guide future research elucidating S. mutans pathogenesis and developing improved preventative and treatment modalities for dental caries. [doi:10.25345/C58Z8P] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Streptococcus mutans, proteome, oxidative stress, Nox, TreR

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Principal Investigators:
(in alphabetical order) 		Jonathon Baker, J. Craig Venter Institute / UC San Diego, USA
Submitting User: jonathon_baker
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