MassIVE MSV000079904

Partial Public PXD004570

Proteome analyses of two ovarian clear cell carcinoma cell lines with or without ARID1A manipulation

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Description

ARID1A, which encodes a component of the SWI/SNF chromatin-remodeling complex, is commonly mutated in ovarian clear cell carcinoma and many other cancer types. We used label-free LC-MS/MS to identify ARID1A-dependent proteome changes in ovarian clear cell carcinoma cell lines. In our first analysis, we compared ARID1A-wildtype ovarian clear cell carcinoma cell line OVCA429 with or without ARID1A CRISPR knockout. In a complementary analysis, we compared ARID1A-mutated ovarian clear cell carcinoma cell line OVISE with or without ARID1A overexpression using a tet-inducible promoter. [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Ovarian clear cell carcinoma ; ARID1A ; BAF250a ; SWI/SNF chromatin-remodeling complex ; Ovarian cancer ; Cancer ; Human ; LC-MS/MS ; Epithelial ovarian cancer ; Label-free quantitation ; OVCA429 ; OVISE

Contact

Principal Investigators:
(in alphabetical order) 		David W. Speicher
Submitting User: agoldman

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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