We performed a comprehensive and label-free quantitative proteomic analysis of the human adenocarcinoma epithelial TNBC cells (MDA-MB-231) treated with Cisplatin (CsP) and Cisplatin with EP (EP+CsP). We identified hundreds of differentially expressed proteins that defines molecular mechanisms involved in cellular responses of MDA-MB-231 cells to ECT. The underlying dataset represents a valuable resource for mechanistic studies and for the validation of knowledge gained from this study in the future using animal models. The systemic data should build a foundation for a better understanding of the mechanisms of the cytotoxicity of the Cisplatin as a potent anticancer drug.
[doi:10.25345/C53W59]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Proteomics, Triple Negative Breast Cancer, Mass Spectrometry, Cisplatin, Electroporation
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Rajeswari Sundararajan, Purdue University, USA |
Submitting User: | uma_aryal |
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