MassIVE MSV000083506

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Proteomic changes in cuprizone induced remyelination and demyelination processes.

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Description

The MS raw files were processed and search in Mascot and SEQUEST through the Proteome Discoverer 2.1 software (Thermo Fisher Scientific). Database searches were performed using the following parameters: Precursor mass tolerance of 10 parts per million (ppm); MSMS mass tolerance of 0.05 Da; Enzyme: Trypsin and up to two missed cleavages were allowed. [doi:10.25345/C5B90Q] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Brain, Cuprizone, Remyelination, Demyelination, LC-MS, Proteomics

Contact

Principal Investigators:
(in alphabetical order) 		Gabor Szilagyi, PTE AOK Department of Biochemistry and Medical Chemistry, Hungary
Submitting User: Janos

Publications

Szilagyi GT, Nawrocki AM, Eros K, Schmidt J, Fekete K, Elkjaer ML, Hyrlov KH, Larsen MR, Illes Z, Gallyas F.
Proteomic changes during experimental de- and remyelination in the corpus callosum.
PLoS ONE. 2020;15(4):e0230249. Epub 2020 Apr 9.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

"N/A" means no results of this type were submitted.
This dataset may not contain all raw spectra data as originally deposited in PRIDE. It has been imported to MassIVE for reanalysis purposes, so its spectra data here may consist solely of processed peak lists suitable for reanalysis with most software.