MassIVE MSV000085912

Partial Public PXD020733

FBXO7 Binds to and Increases the Expression of the p105 Subunit of NF-kB

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Description

Cell lysate from HAP1 cells were separated on several columns, the proteins were digested with trypsin and analysed on a Q Exactive HF-X instrument. [doi:10.25345/C55X71] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: E3 Ubiquitin Ligase ; FBXO7 ; NF-kB

Contact

Principal Investigators:
(in alphabetical order) 		Bertrand Fabre, Techinion, Israel
Submitting User: bertrandfabre31

Publications

Udasin RG, Gottfried Y, Fabre B, Bercovich B, Ziv T, Ciechanover A.
The p105 NF-?B precursor is a pseudo substrate of the ubiquitin ligase FBXO7, and its binding to the ligase stabilizes it and results in stimulated cell proliferation.
Biochem. Biophys. Res. Commun. Epub 2020 Sep 12.

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