MassIVE MSV000093605

Partial Public PXD047631

Heart proteomics of pathological atrial enlargement associated with atrial fibrillation

Description

Atrial fibrillation (AF) remains challenging to prevent and treat. It is associated with increased rates of heart failure, stroke and neurological decline. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to pathology and AF. In the current study, we characterized mouse atria from a 1) pathological model (cardiac-specific transgenic (Tg) that develops dilated cardiomyopathy [DCM] and AF due to reduced protective signalling [PI3K]; DCM-dnPI3K), and a 2) physiological model (cardiac-specific Tg with an enlarged heart due to increased insulin-like growth factor 1 receptor; IGF1R). Atrial enlargement in the DCM-dnPI3K Tg, but not IGF1R Tg, was associated with atrial dysfunction, fibrosis and a heart failure gene expression pattern. Proteomics analysis identified proteins and pathways that were differentially regulated in pathological and physiological atrial enlargement, and provides a resource to study potential drug targets for AF. [doi:10.25345/C5F766J3B] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: heart ; Atrial fibrillation ; atrial enlargement ; drug targets

Contact

Principal Investigators:
(in alphabetical order)
David Greening, Baker Heart & Diabetes Institute, Australia
Submitting User: dwgree
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Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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