The mismatch repair (MMR) family is a highly conserved group of proteins that function in correcting base-base and insertion-deletion mismatches generated during DNA replication. To systematically investigate the mismatch repair pathway, we conducted a proteomic analysis and identified MMR-associated protein complexes using a tandem-affinity purification coupled with mass spectrometry (TAP-MS) method. In total, we identified 262 high-confidence candidate interaction proteins (HCIPs).
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Human ; HEK-293T ; MMR ; TAP
Principal Investigators: (in alphabetical order) |
Dr Junjie Chen |
Submitting User: | ccms |
Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J.
Proteomic Analysis Reveals a Novel MutS Partner Involved in Mismatch Repair Pathway.
Mol. Cell Proteomics. Epub 2016 Jan 31.
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