Contactin 2 (CNTN2), a neuronal guidance molecule, forms transient homodimers. Cryo-electron microscopy reveals that the CNTN2 homodimer forms a T-shaped particle composed of parallel, intertwined monomers. A central homodimeric stalk places headpieces, leveraged by CNTNs to bind heterophilic partners, on either side, indicating that homophilic and heterophilic binding mechanisms are distinct.
[doi:10.25345/C59W0995F]
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: crosslinking
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William Russell, UTMB, USA |
Submitting User: | Bill |
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