MassIVE MSV000096065

Complete Public PXD056731

Mitochondrial DNA affects tau expression and phosphorylation in Alzheimers Disease and aging in humans and cybrid cell lines

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Description

We investigate the role of mitochondrial DNA in Alzheimers Disease pathology using human cybrid cell lines and investigate the relationships between biomarker expression from cybrids and clinically relevant outcomes from the same individuals. Proteomic analysis of cybrids showed significant alterations in pathways related to mitochondrial dysfunction and energy synthesis in AD and mildly cognitively impared cybrids compared to cognitively healthy controls. [doi:10.25345/C54747379] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Alzheimers disease ; mitochondrial dysfunction ; DatasetType:Proteomics

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Principal Investigators:
(in alphabetical order) 		Jill K Morris, University of Kansas Medical Center, USA
Submitting User: KUMC_Prot
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Number of distinct biological replicates across all analyses (original submission and reanalyses) associated with this dataset.

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Originally identified proteins that were automatically remapped by MassIVE to proteins in the SwissProt human reference database.

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Number of distinct proteins quantified across all analyses (original submission and reanalyses) associated with this dataset.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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Number of distinct proteins found to be differentially abundant in at least one comparison across all analyses (original submission and reanalyses) associated with this dataset.

A protein is differentially abundant if its change in abundance across conditions is found to be statistically significant with an adjusted p-value <= 0.05 and lists no issues associated with statistical tests for differential abundance.

Distinct protein accessions are counted across all files submitted in the "Statistical Analysis of Quantified Analytes" category having a "Protein" column in this dataset.

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