MassIVE MSV000086764

Partial Public PXD023803

Phosphoproteomics of ATR Signaling in Prophase I of Mouse Meiosis

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Description

Here we used phosphoproteomics to define meiosis-specific ATR signaling events during prophase I in mice following chemical and genetic ablation of ATR signaling. Quantitative analysis of phosphoproteomes obtained after tissue-specific genetic ablation of the ATR activating 9-1-1 complex or treatment with ATR inhibitor revealed over 49,800 phosphorylation sites from testes samples, of which 401 phosphorylation sites were found to be dependent on both the 9-1-1 complex and ATR kinase. [doi:10.25345/C57N54] [dataset license: CC0 1.0 Universal (CC0 1.0)]

Keywords: Phosphoproteomics, Mouse, Meiosis, ATR singnaling

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Principal Investigators:
(in alphabetical order) 		Marcus Smolka, Cornell University, United States
Submitting User: vitorfaca
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