Severe sepsis and septic shock, which occur with high incidence and are prevalent in the emergency department setting, are among the most common causes of death in hospitalized patients worldwide, and there has been a continuous increase in the incidence of sepsis of approximately 5–10% per year. Endothelial cells constitute an important metabolic organ in the physiological homeostasis of blood vessels and play a pivotal role in orchestrating the inflammatory response triggered by sepsis or endotoxemia. The secretome is defined as the subset of the proteome that contains all the proteins actively exported by a cell following a particular event.
[dataset license: CC0 1.0 Universal (CC0 1.0)]
Keywords: Secretome ; Biomarker ; SILAC ; Sepsis ; Moesin
Principal Investigators: (in alphabetical order) |
Sangkyu Lee, College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Republic of Korea, N/A |
Submitting User: | ccms |
Kwon OK, Lee W, Kim SJ, Lee YM, Lee JY, Kim JY, Bae JS, Lee S.
In-depth proteomics approach of secretome to identify novel biomarker for sepsis in LPS-stimulated endothelial cells.
Electrophoresis. 2015 Dec;36(23):2851-8. Epub 2015 Sep 13.
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